October 4, 2023
Gastric and Duodenal Ulcers

Difference Between Gastric and Duodenal Ulcers

What is a Gastric Ulcer?

Gastric ulcers are less common than PUD and occur more often in older age groups. The ulcer is located on the lesser curvature. Chronic ulcers can cause excessive bleeding and erode the artery of the spleen on the posterior surface. Chronic gastric ulcers can cause carcinoma. These ulcers are therefore considered malignant until proven otherwise.

What is Duodenal Ulcer?

Most commonly, duodenal lesions occur on the first part of the duodenum’s posterior surface. Chronic ulcers can penetrate the mucosa, causing fibrosis or bleeding profusely (if they are related to vessels). It was suggested that “kissing Ulcers” be used to describe anterior or posterior ulcers which had healed and caused fibrosis. It is rare for chronic duodenal lesions to become malignant.

Difference between Gastric and Duodenal Ulcers

Both types share a bacterial origin as well as NSAID-induced acidity that causes further progression. Numerous literature analyses have revealed that clinical features are not enough to distinguish between the two types. The pain will radiate from the epigastric area to the back. Eating relieves the pain. Complications like stenosis and perforation can present as other symptoms such as vomiting or bleeding.

Management is through antisecretory drugs and the Pylori elimination regime. In advanced cases, surgical treatment may be required to relieve the condition. Duodenal Ulcers are smaller in diameter and more common.

Gastric ulcers are more common in the lower curvature of the stomach while duodenal ones appear in the first part of the duodenum. Duodenal Ulcers can have bleeding, fibrosis, and perforation. Gastric Ulcers tend to be more prone to bleeding. Gastric ulcers are more likely than duodenal to progress to cancer in their chronic form.

The differences between gastric and duodenal uvulas that were previously cited as being demonstrative are no longer considered to be true, and symptoms are not thought to differ much. These conditions have similar management principles, which are preceded by a similar investigation process. Anatomical location only influences the pathological, histological, and complications of gastric and duodenal esophageal ulcers. Gastric and duodenal peptic ulcers are grouped together under the term peptic disease.

Definition of Gastric ulcers

Open sores develop on the inner lining of the stomach. These ulcers are a form of peptic, which is a term used to describe ulcers that may develop in the small intestine or esophagus. Gastric ulcers are specific to the stomach. They’re characterized by erosions and breaks in the mucosal lining that protects the stomach wall. They can be of varying size and depth and are most commonly found in the stomach lining, where they are exposed to acid and digestive enzymes.

Untreated gastric ulcers may cause discomfort and pain, and even lead to complications. Gastric ulcers are most commonly caused by Helicobacter pylori infection (H. pylori), although they can be caused by other factors such as long-term nonsteroidal anti-inflammatory drugs (NSAIDs), or the disruption of the balance between the stomach’s aggressive and protective factors. Gastric ulcers can be managed and prevented by a prompt

Gastric ulcers

Definition of Duodenal ulcers

The duodenal is a type of peptic ulcer. It develops on the first part, or the duodenum, of the small intestine. These are open sores, or erosions, that develop in the lining of the duodenal walls. Duodenal Ulcers are more common than stomach ulcers, and they are often characterized by a unique set of symptoms.

The duodenum receives partially digested foods from the stomach and breaks them down further with digestive enzymes. When there is a balance between protective factors and aggressive ones that can damage the duodenum’s lining, it leads to ulcers.

Helicobacter pylori is the primary cause of duodenal Ulcers. This bacterium weakens the mucous lining of the duodenum allowing stomach acids and other digestive fluids to irritate it and cause an ulcer. Duodenal Ulcers can also be caused by excessive stomach acid production, the use of nonsteroidal inflammatory drugs (NSAIDs), stress, smoking, and genetic predisposition.

These ulcers are often characterized by a burning, gnawing, or stabbing pain in the upper abdomen. This usually occurs between meals or at night. These ulcers usually improve when you eat or take antacids. Untreated duodenal eczema can cause complications, such as bleeding, obstruction, or perforation.

Duodenal ulcers

Duodenal ulcers must be treated promptly and appropriately. Some treatment options include medications that reduce stomach acid, eliminate H. pylori, and promote healing. Lifestyle changes, such as managing stress and avoiding trigger food, can play a part in the prevention and management of duodenal ulcers. Surgery may be required in severe cases or if complications occur.

Etiology and Risk Factors

There are some factors that are common to both types of ulcers, but the etiology can be different.

 Here are some of the main etiological and risk factors associated with both types:

Helicobacter Pylori (Pylori), the primary cause of ulcers in the stomach, is a bacterium. pylori weaken stomach mucous, allowing stomach acids to cause ulcers.

1 NSAIDs (nonsteroidal anti-inflammatory medications): The stomach lining can be irritated by prolonged or excessive use of NSAIDs such as aspirin and ibuprofen. This leads to gastric ulcers. Stress and lifestyle: Although stress does not cause gastric ulcers directly, it can exacerbate them, especially if combined with other factors such as smoking, excessive alcohol intake, and irregular eating patterns.

2. Duodenal Ulcers Etiology: Helicobacter pylori Infection: Like gastric ulcers, H. pylori is the primary cause. The bacteria cause the mucous membrane in the duodenum to weaken, making it more vulnerable to stomach acids. b. Gastric acid production: Some people naturally produce more stomach acid than others, increasing the risk of duodenal ulcers. Stress and lifestyle factors: Smoking, excessive alcohol intake, irregular eating habits, and chronic anxiety can all contribute to duodenal ulcers.

Individual risk factors can influence both gastric and duodenal ulcers.

1. Age: As you age, the risk of developing an ulcer increases.

2. Family history: A family history of stomach ulcers, or a genetic disposition to develop ulcers can increase your risk of getting them.

3. Previous ulcer history: People who have previously had an ulcer are more likely to develop a new one.

4. Certain medications can cause ulcers: These include NSAIDs and other anticoagulants, such as corticosteroids.

5. Severe medical conditions: Some conditions such as liver, lung, or kidney diseases may increase your risk of developing an ulcer.

6. Alcohol consumption is excessive: Drinking alcohol in excess can damage and irritate the stomach and duodenal walls, increasing the chances of developing ulcers.

7. Stress and anxiety: Both chronic stress and anxiety may contribute to the development of ulcers.

While these factors can increase the likelihood of developing duodenal and gastric ulcers, there are many different susceptibilities, and not everyone who has these risk factors is likely to develop an ulcer.

Clinical Presentation

There are some similarities between the clinical presentations of duodenal and gastric ulcers, but there are also some differences. Here are some of the most common clinical presentations for gastric and duodenal Ulcers.

Clinical Presentation of Gastric Ulcers

Pain in the upper abdomen: Gastric ulcers are characterized by a burning, dull or persistent pain. Pain is usually felt in the gastric area, between the chest and belly button. Gastric Ulcers can cause nausea and vomiting in some individuals, particularly after eating certain foods or taking certain medications.

Loss of appetite: Due to the discomfort caused by gastric ulcers, a person may lose weight unintentionally. Gastric Ulcers can cause excessive belching or bloating.

Bloody stools or vomiting: In severe cases of gastric ulcers, bleeding can occur.

Burning or gnawing: Duodenal Ulcers are characterized by a burning or biting pain that is felt in the upper abdomen. This pain usually occurs between the breastbone or navel. Pain is described as recurring in episodes. It can be temporarily relieved by taking antacids or eating. Duodenal Ulcers can cause pain at night or early in the morning when the stomach is empty. This can cause discomfort and disrupt sleep patterns.

Duodenal Ulcers: These can cause a feeling of hunger or emptiness that is relieved when you eat.

Vomiting and nausea: Duodenal Ulcers can cause nausea and vomiting. However, this is much less common than gastric ulcers. Hematemesis or melena? Like severe gastric ulcers duodenal ulcers may cause bleeding resulting in bloody vomiting, or dark, tarry stool.

Not all ulcer symptoms will be present in every individual. Some individuals are asymptomatic, and discover an ulcer only during diagnostic procedures. Consult a medical professional if you suspect that you may have an ulcer, or if you are experiencing any symptoms.


Treatment for gastric or duodenal ulcers is aimed at relieving symptoms, promoting ulcer healing, and preventing complications. Specific treatment plans may differ depending on factors such as the cause of the ulcer or the patient.

Here are some common treatment options for duodenal and gastric ulcers:

1. Medicines: These medications lower stomach acid production and allow the ulcer to heal. First-line treatment of both duodenal and gastric ulcers is often PPIs.

2. Pylori eradication: If an ulcer is caused due to H. pylori, antibiotics such as clarithromycin or metronidazole are used in combination with PPIs.

3. Antacids or acid-reducing medication: These over-the-counter medications can temporarily relieve symptoms by neutralizing stomach acids or reducing their production. These medications are usually used in combination with other treatments. Cytoprotective Agents: Medicines like sucralfate can be prescribed to form a protective layer over the ulcer. This will promote healing and reduce symptoms. e.

4. Alternatives to NSAIDs: If NSAIDs caused the ulcer, other pain relievers and medications that protect the stomach (such as COX-2 selective inhibitors) can be prescribed.

5. Lifestyle modifications:  Avoid trigger foods. Spicy, acidic, and fatty food can worsen ulcer symptoms. These foods can be reduced by limiting or avoiding them. b. Smoking cessation. Smoking can slow ulcer healing and increase complications. It is important to quit smoking in order to manage ulcers. Exercise, meditation, and counseling are all ways to reduce stress, which can contribute to the development of ulcers. Regular eating habits can promote healing and maintain a stable stomach environment.

6. Monitoring and follow-up: It is important to have regular check-ups to assess the healing of the ulcer and to make any necessary adjustments to your treatment plan. After eradication treatment, repeat testing for Pylori may be done to ensure success.

7. Surgical intervention: Surgery may be required in rare cases where ulcers don’t respond to medication or complications occur (e.g., bleeding, perforation). The surgical options include removing an ulcer or creating a method to stop acid production.


Consult a medical professional to get a proper diagnosis and advice on the best treatment for duodenal or gastric ulcers. It is important to seek medical attention as soon as possible if you are self-medicating or ignoring your symptoms.


Untreated peptic and gastric ulcers can cause discomfort and even lead to complications. It is important to know the differences between duodenal and gastric ulcers in order to diagnose and treat them properly. Duodenal and gastric ulcers are both found in the small intestine.

Gastric ulcers are often characterized by gastric discomfort, nausea, vomiting, and loss of appetite. Duodenal ulcers, on the other hand, present with a burning or gnawing sensation, as well as hunger-like symptoms and nocturnal discomfort.