October 4, 2023
Sodium Butyrate and Calcium Magnesium Butyrate

Sodium Butyrate and Calcium Magnesium Butyrate Between the top 5 difference

Overview of Sodium Butyrate (SB) and Calcium Magnesium Butyrate

  1. Overview of Sodium butyrate: Sodium butyrate is derived by butyric acids. It is used as a dietary supplement and has many biological effects. Studies have shown that it is beneficial to the digestive system. Its anti-inflammatory qualities are well-known, as is the ability to promote gut wellness. The most common oral sodium butyrate supplement is enteric-coated tablets or capsules. 
  2. Overview: Calcium Magnesium butyrate: Calcium magnesium is butyric acid, calcium and magnesium combined. Similar to sodium butyrate, it also contains essential minerals. Calcium and magnesium are added to the compound in order to increase butyrate’s effects and offer additional health benefits. Magnesium and calcium are essential for many physiological processes. For oral supplementation, you can take enteric-coated calcium magnesium butyrate capsules or tablets.

The mechanisms of sodium butyrate and calcium magnesium butyrate are similar and have potential health benefits. This is especially true for supporting digestive health and reducing inflammation.

Calcium magnesium butyrate differs from sodium butyrate in that it contains calcium and magnesium. This may offer additional benefits in terms of bone and physiological function.

Sources of Production

  1. Sources and production of Sodium Butyrate: Sodium Butyrate can be derived from both natural and synthetic sources. Butyric acid is found in butter, ghee, and certain animal fats. Most sodium butyrate production is synthetic. In the production of sodium butyrate, butyric is combined with sodium hydroxide. It is important to ensure that the sodium butyrate in pharmaceuticals and nutritional supplements are pure and consistent. 
  2. Calcium Magnesium Butyrate: It is primarily produced synthetically for use as a food supplement. Butyric acid is combined with either calcium carbonate or magnesium carbonate to produce Calcium Magnesium Butyrate. The process of synthesizing the compound ensures that all the components, including magnesium, calcium, and butyric acid are controlled and standardized.

While sodium butyrate, calcium magnesium butyrate, and butyric acids can be synthesized, natural sources of butyric acids, like butter and ghee are not the synthetic compounds that are used as supplements.

Natural sources of butyric acids contain different amounts, without the carriers (sodium calcium and magnesium), found in supplement forms.

What are Sodium Butyrates?

This is a type of short-chain fatty acid (SCFA) that belong to a certain group. It is a salt of butyric and butanoic acid. The chemical formula of sodium butyrate is C4H7NaO2.

Sodium Butyrates
Image 01: Sodium Butyrates

The fermentation of dietary fibres by bacteria in the colon produces butyric acid. These naturally occurring fatty acids is found in butter, ghee and animal fats. The amounts of sodium butyrate naturally occurring in these foods is relatively low.

The potential health benefits of sodium butyrate have gained much attention in both scientific research and the healthcare industry. It is essential for many physiological processes.

It has anti-inflammatory properties, and it supports gut health and integrity. Also, sodium butyrate was studied for its effects on gene regulation and possible anticancer properties.

Enteric-coated capsules or tablets are available as a dietary complement. Enteric coatings ensure that sodium butyrate is delivered to the intestines, without it being released prematurely in the stomach. This compound is most beneficial when consumed in the lower gastrointestinal system.

The sodium butyrate dosage and administration should only be done under the supervision of a health care professional. This is because individual needs and conditions will determine the proper dose and administration.

What are Calcium Magnesium Butyrates?

Calcium magnesium butyrate consists of calcium, magnesium and butyric acids. The complex structure is created by binding two molecules of butyric acids with calcium and magnesium ions. Calcium magnesium butyrate has the chemical formula (C4H7O2)2CaMg.

Calcium Magnesium Butyrates
Image 02: Calcium Magnesium Butyrates

Butyric Acid, the active ingredient in calcium magnesium butyrate is a short-chain fatty acid that is produced by bacterial fermentation in the colon. It is found naturally in whole grains, beans, fruits and vegetables. Butyric acid is not found in high concentrations in many of these foods.

Calcium magnesium butyrate, which contains butyric and calcium acids, has additional health benefits. It may also have synergistic effects.

Calcium is an important mineral that is known for its role as a bone-healthy mineral and in many physiological processes. Magnesium, another essential mineral, is vital for muscle and nerve functions, energy production and enzyme reactions.

Calcium magnesium butyrate, also known as calcium magnesium butyrate, is used primarily as a nutritional supplement. Similar to sodium butyrate, it is available as enteric-coated capsules or tablets. The enteric coating helps the compound reach the lower gastrointestinal tract where it can have its effect.

Calcium magnesium butyrate is a specific formulation that includes calcium and magnesium to maximize the benefits of butyric acids, as well as the added advantages of these essential minerals.

It is important to speak with a health professional before taking calcium magnesium butyrate, as the dosage and method of administration can vary depending on your individual needs and conditions.

Sodium Butyrate and Calcium Magnesium Butyrate in Tabular Form

Here’s a comparison table between Sodium Butyrate and Calcium Magnesium Butyrate:

Aspect Sodium Butyrate Calcium Magnesium Butyrate
Chemical Formula C4H7NaO2 (C4H7O2)2Ca, (C4H7O2)2Mg
Composition Sodium salt of butyric acid Combination of calcium and magnesium salts of butyric acid
Role and Function Used as a dietary supplement and pharmaceutical agent Often used as a dietary supplement to provide butyric acid with added minerals
Delivery Form Usually available as a powder or capsule Typically available as a capsule or tablet
Gastrointestinal Effects Can influence gut health and function Aimed at supporting gastrointestinal health and promoting butyric acid delivery to the intestines
Butyric Acid Source Provides butyric acid to the body Provides butyric acid while also supplying calcium and magnesium
Metabolism and Absorption Rapidly absorbed in the intestines The calcium and magnesium salts may affect the absorption of butyric acid
Health Benefits Associated with gut health, anti-inflammatory effects, and more Similar benefits as sodium butyrate with potential additional effects due to calcium and magnesium
Dosage and Usage Dosage can vary based on intended use Dosage may vary based on the product and intended effect
Considerations May have a more pronounced taste and odor The presence of calcium and magnesium should be considered in cases of mineral sensitivity

Please note that the effects and usage of these compounds can vary based on individual factors, specific health conditions, and intended purposes. Always consult with a healthcare professional before starting any new dietary supplements or treatments.

What are the similarities between Sodium Butyrate and Calcium Magnesium Butyrate?

  1. Active Component: Butyric acid is the active component in both sodium butyrate (and calcium magnesium butyrate). Butyric Acid is a short-chain fatty acid with potential health benefits. This is especially true for the digestive system. 
  2. Gastrointestinal health: Both compounds were studied for their positive effect on gastrointestinal well-being. They can help maintain the integrity of the lining of the gut, encourage the growth of good bacteria in the gut, and regulate inflammation processes. 
  3. Antiinflammatory Properties: Calcium magnesium butyrate, and sodium butyrate have anti-inflammatory properties. They can reduce inflammation in the intestine and possibly in other parts, which contributes to overall health and well-being. 
  4. Gene Expression Regulation: Both compounds are known to regulate gene expression. They can influence histone acetylation, gene transcription and other cellular processes. 
  5. Supplement forms: Both Sodium Butyrate and Calcium Magnesium Butyrate are available as dietary supplements in similar forms, typically as enteric-coated tablets or capsules. Enteric coatings ensure that compounds are released into the lower digestive tract for maximum absorption.

While there are some similarities between the two compounds, calcium and magnesium added to calcium magnesium butyrate can provide additional mineral supplements and have potential synergistic benefits. It’s best to consult a health professional about the specific dosage and administration of each compound.

Health Benefits and Therapeutic Applications

These compounds have been evaluated for their therapeutic and health benefits. These compounds have a number of notable health benefits.

  1. Gastrointestinal health: Sodium magnesium butyrate (and calcium butyrate) are known to promote gastrointestinal health. They can maintain the integrity and health of the lining of the gut. They also regulate the inflammatory response in the gut. These effects can be beneficial in conditions like inflammatory bowel diseases (IBD), IBS, and leaky gut syndrome. 
  2. Antiinflammatory Effects: These compounds have anti-inflammatory effects, which may help reduce inflammation of the gastrointestinal tract as well as other areas of the body. This anti-inflammatory effect may help manage inflammatory conditions like ulcerative colitis or Crohn’s Disease. 
  3. Gene Expression Regulation: Calcium magnesium butyrate, and sodium butyrate were studied to determine their effect on gene expression. They may influence gene transcription and histone acetylation, which could affect various cellular processes. These compounds have shown promising results in regulating gene transcription in cancer cells. This may have implications for cancer prevention and therapy. 
  4. Neurological health: Recent research suggests that sodium butyrate or butyric acids may have beneficial effects on neurological well-being. They could contribute to neuroprotection and improve cognitive function. They also support the health of brain cell. These effects are being studied in relation to neurodegenerative diseases like Alzheimer’s and Parkinson’s. 
  5. Metabolic health: Calcium magnesium butyrate sodium butyrate and sodium butyrate may have benefits. These compounds were studied to determine if they could increase insulin sensitivity, regulate glucose metabolism, and influence lipid metabolism. These effects are crucial for conditions such as diabetes, metabolic syndrome, and obesity.
  6. Potent anti-cancer properties: Were studied. They can cause cell cycle disruption, inhibit cancer cell proliferation, and promote apoptosis among certain cancer types. These compounds have a lot of potential as cancer therapies, but more research is needed to understand their full potential.

Though sodium butyrate, calcium magnesium butyrate, and other compounds show promise, more research needs to be completed on them, and their specific therapeutic applications may vary widely.

Healthcare professionals should determine the appropriate dosage, duration of treatment, and administration based on an individual’s circumstances and health condition.

Safety and side effects

Sodium Butyrate and Calcium Magnesium Butyrate can be used safely as dietary supplements. As with any medication or supplement, there are side effects that should be considered.

. Here are some key points about safety and side effects:

  1. Most people tolerate sodium butyrate or calcium magnesium butyrate: When they are taken in the recommended dose range. Adverse reactions are usually mild and transient. 
  2. Gastrointestinal Effects: Mild gastrointestinal symptoms, such as flatulence, abdominal pain, or diarrhea, are the most frequently reported side effects. These side effects are temporary and usually resolve when the drug is used regularly or the dosage is adjusted. 
  3. Individual Sensitivities: Some people may be more sensitive than others to the effects sodium butyrate, calcium magnesium butyrate. They may also experience stronger gastrointestinal symptoms and other adverse effects. It is best to consult a health professional if you have had a history with gastrointestinal disorders. 
  4. Drug interactions: Calcium magnesium butyrate, sodium butyrate or butyrate can interact with some medications. Consult your doctor if you have any underlying conditions or are on prescription medication. 
  5. Allergic reactions: Are rare but can happen to sodium butyrate or calcium magnesium butyrate or individuals who have an allergy or hypersensitivity to any component. Stop using the product immediately if you experience any allergic symptoms, such as rash, swelling or itching, or difficulty breathing. 
  6. Pregnancy & Breastfeeding: Limited data is available on the safety of calcium magnesium butyrate and sodium butyrate when pregnant or breastfeeding. If you are pregnant or planning to get pregnant, it is best to consult a health professional before taking these supplements. 
  7. Variations in Response: The response of each individual to calcium magnesium butyrate or sodium butyrate can vary. Start with the lowest dose and then monitor your body’s reaction. Consult a health professional if you are experiencing any unusual symptoms or have concerns.

It is always best to consult a healthcare professional such as a registered dietitian or doctor before beginning any new dietary supplements to ensure that it is suitable for your personal health needs, and to determine the appropriate dosage and duration.


Both sodium butyrate and calcium magnesium health butyrate offer potential benefits and therapeutic applications, respectively.

While sodium butyrate is the sodium salt of butyric acid, calcium magnesium butyrate combines butyric acid with calcium and magnesium ions for even greater therapeutic applications. Both compounds are often taken as dietary supplements.

These compounds share similarities in terms of their active component (butyric acid), benefits for gastrointestinal health, anti-inflammatory properties, and potential gene expression regulation effects. Their research has explored their ability to support gut health while decreasing inflammation levels and regulating multiple cellular processes.

Butyrate and calcium magnesium butyrate have shown promise in areas such as digestive health, neurological health, metabolic health, and potentially anti-cancer properties; however, more research must be conducted to fully explore their therapeutic potential and identify any specific applications.